New onset hyperglycemia attributed to renal cell carcinoma

Sarcomatoid Transrormation of Chromophobe Renal Cell Carcinoma

Dyspnea as the First Manifestation of Silent Renal Cell Carcinoma

Renal cell carcinoma (RCC) accounts for only 3% of adult malignancies, and the lung is the most common site of metastasis of this tumor, which may be accompanied by pleural metastasis. However, solitary pleural involvement is very rare and its presentation with dyspnea as the first manifestation of RCC is extremely rare.We describe a 39-year-old male with episodes of dyspnea dating back 6...

Sarcomatoid Chromophobe Renal Cell Carcinoma with Heterologous Component

Clear cellrenal cell carcinoma (RCC) is the most common malignant renal tumor in adults, while chromophobe RCC (CRCC) is the third most common. Any subtypes of RCC can undergo sarcomatoid differentiation, but heterologous differentiation in sarcomatoid area is very rare in RCC. Here a61-year male is presented with hematuria and palpable mass. Clinicoradiologically, RCC was considered and left r...

Metastatic Renal Cell Carcinoma to the Humerus Bone: A Report of Two Cases

Renal cell carcinoma (RCC) is an aggressive malignancy which can metastasize to the bone. Long bones or the small bones of the limbs could be rarely the destinations for metastatic RCCs. We report two cases of metastatic RCC to the humerus bone with the initial presentation of pathological fracture. The pathologists must be aware of metastatic RCC to the arm and consider it in the differential ...

Renal-cell carcinoma: a step closer to a new classification.

Until the advent of next-generation sequencing, somatic genetic changes common in sporadic renal-cell carcinoma were largely unknown. Mutations in the VHL gene, discovered by linkage analysis in hereditary renal-cell carcinoma, had been the focus of genetics research for many years for this type of cancer. Located on chromosome 3p, VHL is a tumour suppressor gene universally mutated in the here...